House: Meet The Cast

From her introduction to television as Lisa E on MTV's "Awake on the Wild Side" to her role as "Dr. Lisa Cuddy" on HOUSE, Lisa Edelstein is no stranger to fearless roles. In the past several years, Edelstein has portrayed Rob Lowe's call-girl girlfriend on "The West Wing," the transsexual boyfriend of James LeGros on "Ally McBeal," David Conrad's lesbian sister on "Relativity," an Orthodox Jew losing custody of her child on "Family Law" and James Spader's love interest on "The Practice."

Additional television credits include her series regular role on "Leap of Faith" and guest turns on "Seinfeld," "Without a Trace," "Frasier," "Felicity" and "ER." Edelstein also works extensively in the realm of voiceover, most recently as "Mercy Graves" on the animated "Superman" and "Justice League" series as well as guest spots on AMERICAN DAD and KING OF THE HILL.